Using single-cell and spatial transcriptomics to dissect cellular heterogeneity during melanoma growth and metastasis

cross section of a spatial transcriptomic image of a melanoma cell
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Panagiotis Karras, Ph.D.Speaker
Jackie Oberst, Ph.D.Moderator
This webinar is brought to you by the Science/AAAS Custom Publishing Office.

Cancer is a conversation between the tumor and its surrounding host cells. Within this space, known as the tumor microenvironment, the tumor interacts with blood vessels, immune cells, fibroblasts, and the extracellular matrix. Tumors influence the tumor microenvironment by releasing extracellular signals, promoting tumor angiogenesis, and inducing peripheral immune tolerance. Likewise, the immune cells in the TME respond by releasing cytokines and antibodies to reduce the growth and evolution of the cancerous cells.

Single-cell and spatial transcriptomics techniques allow researchers to tap into the conversation by resolving the diversity and trajectory of cancer cell states, spatially and temporally, within tumor microenvironments. In this webinar, our speaker will discuss how these techniques can be used to elucidate the mechanisms of specific niche signals used to reprogram melanoma cells to support growth and metastasis. He will reveal how understanding tumor microenvironments with spatial context provides insights that can encourage the development of novel therapeutic strategies to intercept cancer cell growth via inference with important microenvironmental cues.

In this webinar, viewers will:

  • Explore the benefits of performing spatial transcriptomics for translational oncology research
  • Discover how to combine single-cell and spatial transcriptomics data with other computational data, to create a spatial and temporal map of a tumor microenvironment
  • Understand the origins of a spatially localized perivascular niche that contributes to tumorigenic competence
  • Have an opportunity to ask questions during the live broadcast.

This webinar will last for approximately 60 minutes.

Sponsored By:
Resolve Biosciences