Science Signaling
- Volume 16
- Issue 780
- 11 Apr 2023
ONLINE COVER This week, Gabriel and Streicher show in mice that opioids activate a pathway in the spine that inhibits their efficacy. This pathway is mediated by the kinase AMPK and can be blocked by HSP90 inhibitors. The image shows opioid-induced phosphorylation of ERK (green) in the spinal cord of mice that lack AMPK in certain neurons.
Image: Gabriel and Streicher/Science SignalingResearch ArticlesBy
- Laurent Schmied
- Thuy T. Luu
- et al.
SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency
Research ArticlesBy
- Katherin A. Gabriel
- John M. Streicher
HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop
Editors' ChoiceBy
- Amy E. Baek
Metastatic dormancy needs STING
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Science Signaling is a weekly, online journal for the life sciences. We publish studies that uncover basic mechanisms underlying biological processes in all organisms. We are particularly interested in studies that provide new insights into physiology, delineate mechanisms that cause disease, identify potential therapeutic targets and strategies, and characterize the effects of drugs.
mission & scopeEditors’ Choice
11 Apr 2023
Metastatic dormancy needs STING
4 Apr 2023
Light sleeper? Eat more protein
28 Mar 2023
Blebby survivors
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