Science Immunology
- Volume 8
- Issue 82
- Apr 2023
ONLINE COVER Intertwined Lineages. This month’s cover depicts two trees whose trunks have grown together and physically attached, a natural phenomenon known as inosculation. These trees represent two separate developmental lineages of T cells that can both yield T follicular regulatory (Tfr) cells. Using single-cell analysis techniques to study Tfr cells isolated from human tonsils, Le Coz et al. documented the presence of distinct Tfr subsets derived from either natural regulatory T cells or T follicular helper cells, each with distinct functional properties and localization within lymphoid tissues.
Credit: Ella Maru StudioResearch ArticlesBy
- Zhilin Li
- Salli Antila
- et al.
Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation
ReviewBy
- Jhan-Jie Peng
- Limei Wang
- et al.
Metabolic challenges and interventions in CAR T cell therapy
Research ArticlesBy
- Bibo Zhu
- Xiaoqin Wei
- et al.
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
Research ResourceBy
- Huiming Xia
- Joshua McMichael
- et al.
Computational prediction of MHC anchor locations guides neoantigen identification and prioritization
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Reviews
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Science Immunology publishes original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques.
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