Research

Research Article

Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation

by

Zhilin Li
Salli Antila
Harri Nurmi
Dmitri Chilov
Emilia A. Korhonen
Shentong Fang
Sinem Karaman
Britta Engelhardt
Kari Alitalo

Science ImmunologyVol. 8, NO. 8214 Apr 2023

Research Article

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

by

Bibo Zhu
Xiaoqin Wei
Harish Narasimhan
Wei Qian
Ruixuan Zhang
In Su Cheon
Yue Wu
Chaofan Li
Russell G. Jones
Mark H. Kaplan
Robert A. Vassallo
Thomas J. Braciale
Lindsay Somerville
Jerry R. Colca
Akhilesh Pandey
Patrick E. H. Jackson
Barbara J. Mann
Connie M. Krawczyk
Jeffrey M. Sturek
Jie Sun

Science ImmunologyVol. 8, NO. 8214 Apr 2023

Research Resource

Computational prediction of MHC anchor locations guides neoantigen identification and prioritization

by

Huiming Xia
Joshua McMichael
Michelle Becker-Hapak
Onyinyechi C. Onyeador
Rico Buchli
Ethan McClain
Patrick Pence
Suangson Supabphol
Megan M. Richters
Anamika Basu
Cody A. Ramirez
Cristina Puig-Saus
Kelsy C. Cotto
Sharon L. Freshour
Jasreet Hundal
Susanna Kiwala
S. Peter Goedegebuure
Tanner M. Johanns
Gavin P. Dunn
Antoni Ribas
Christopher A. Miller
William E. Gillanders
Todd A. Fehniger
Obi L. Griffith
Malachi Griffith

Science ImmunologyVol. 8, NO. 8207 Apr 2023

Research Article

Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation

by

Thomas Fabre
Alexander M. S. Barron
Stephen M. Christensen
Shoh Asano
Kathryn Bound
Matthew P. Lech
Marc H. Wadsworth
Xiao Chen
Chang Wang
Ju Wang
James McMahon
Franklin Schlerman
Alexis White
Kellie M. Kravarik
Andrew J. Fisher
Lee A. Borthwick
Kevin M. Hart
Neil C. Henderson
Thomas A. Wynn
Ken Dower

Science ImmunologyVol. 8, NO. 8207 Apr 2023

Research Article

Human T follicular helper clones seed the germinal center–resident regulatory pool

by

Carole Le Coz
Derek A. Oldridge
Ramin S. Herati
Nina De Luna
James Garifallou
Emylette Cruz Cabrera
Jonathan P. Belman
Dana Pueschl
Luisa V. Silva
Ainsley V. C. Knox
Whitney Reid
Samuel Yoon
Karen B. Zur
Steven D. Handler
Hakon Hakonarson
E. John Wherry
Michael Gonzalez
Neil Romberg

Science ImmunologyVol. 8, NO. 8207 Apr 2023

Research Article

Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex

by

Taiichiro Shirai
Akiko Nakai
Emiko Ando
Jun Fujimoto
Sarah Leach
Takao Arimori
Daisuke Higo
Floris J. van Eerden
Janyerkye Tulyeu
Yu-Chen Liu
Daisuke Okuzaki
Masanori A. Murayama
Haruhiko Miyata
Kazuto Nunomura
Bangzhong Lin
Akiyoshi Tani
Atsushi Kumanogoh
Masahito Ikawa
James B. Wing
Daron M. Standley
Junichi Takagi
Kazuhiro Suzuki

Science ImmunologyVol. 8, NO. 8131 Mar 2023

Research Article

NK-like CD8⁺ γδ T cells are expanded in persistent Mycobacterium tuberculosis infection

by

Roshni Roy Chowdhury
John R. Valainis
Megha Dubey
Lotta von Boehmer
Elsa Sola
Julie Wilhelmy
Jing Guo
Oliver Kask
Mane Ohanyan
Meng Sun
Huang Huang
Xianxi Huang
Patricia K. Nguyen
Thomas J. Scriba
Mark M. Davis
Sean C. Bendall
Yueh-hsiu Chien

Science ImmunologyVol. 8, NO. 8131 Mar 2023

Research Article

DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification

by

Qian Hao
Chuanzong Zhan
Chaoyang Lian
Simin Luo
Wenyi Cao
Binbin Wang
Xia Xie
Xiaofei Ye
Tuantuan Gui
Claudia Voena
Chiara Pighi
Yanyan Wang
Ying Tian
Xin Wang
Pengfei Dai
Yanni Cai
Xiaojing Liu
Shengqun Ouyang
Shiqi Sun
Qianwen Hu
Jun Liu
Youqiong Ye
Jingkun Zhao
Aiguo Lu
Ji-Yang Wang
Chuanxin Huang
Bing Su
Fei-Long Meng
Roberto Chiarle
Qiang Pan-Hammarström
Leng-Siew Yeap

Science ImmunologyVol. 8, NO. 8124 Mar 2023

Research Article

The transcription factor Mef2d regulates B:T synapse–dependent GC-T_FH differentiation and IL-21–mediated humoral immunity

by

Ye-Ji Kim
Jeein Oh
Soohan Jung
Chan Johng Kim
Jinyong Choi
Yoon Kyung Jeon
Hyun Jik Kim
Ji-Won Kim
Chang-Hee Suh
Yoontae Lee
Sin-Hyeog Im
Shane Crotty
Youn Soo Choi

Science ImmunologyVol. 8, NO. 8124 Mar 2023

Research Resource

Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation

by

Yingying Huo
Linjie Wu
Aiming Pang
Qing Li
Fang Hong
Caiying Zhu
Zining Yang
Weiqian Dai
Yawei Zheng
Qianqian Meng
Jiali Sun
Shihui Ma
Linping Hu
Ping Zhu
Fang Dong
Xin Gao
Erlie Jiang
Sha Hao
Tao Cheng

Science ImmunologyVol. 8, NO. 8117 Mar 2023

Research Article

A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis

by

Chunjing Bao
Ouyang Chen
Huaxin Sheng
Jeffrey Zhang
Yikai Luo
Byron W. Hayes
Han Liang
Wolfgang Liedtke
Ru-Rong Ji
Soman N. Abraham

Science ImmunologyVol. 8, NO. 8117 Mar 2023

Research Article

An XBP1s–PIM-2 positive feedback loop controls IL-15–mediated survival of natural killer cells

by

Shoubao Ma
Jingjing Han
Zhenlong Li
Sai Xiao
Jianying Zhang
Jiazhuo Yan
Tingting Tang
Tasha Barr
Andrew S. Kraft
Michael A. Caligiuri
Jianhua Yu

Science ImmunologyVol. 8, NO. 8110 Mar 2023

Research Article

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

by

Filippo Bianchini
Virginia Crivelli
Morgan E. Abernathy
Concetta Guerra
Martin Palus
Jonathan Muri
Harold Marcotte
Antonio Piralla
Mattia Pedotti
Raoul De Gasparo
Luca Simonelli
Milos Matkovic
Chiara Toscano
Maira Biggiogero
Veronica Calvaruso
Pavel Svoboda
Tomás Cervantes Rincón
Tommaso Fava
Lucie Podešvová
Akanksha A. Shanbhag
Andrea Celoria
Jacopo Sgrignani
Michal Stefanik
Vaclav Hönig
Veronika Pranclova
Tereza Michalcikova
Jan Prochazka
Giuditta Guerrini
Dora Mehn
Annalisa Ciabattini
Hassan Abolhassani
David Jarrossay
Mariagrazia Uguccioni
Donata Medaglini
Qiang Pan-Hammarström
Luigi Calzolai
Daniel Fernandez
Fausto Baldanti
Alessandra Franzetti-Pellanda
Christian Garzoni
Radislav Sedlacek
Daniel Ruzek
Luca Varani
Andrea Cavalli
Christopher O. Barnes
Davide F. Robbiani

Science ImmunologyVol. 8, NO. 8110 Mar 2023

Research Article

Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer

by

Yini Zhu
Yun Zhao
Jiling Wen
Sheng Liu
Tianhe Huang
Ishita Hatial
Xiaoxia Peng
Hawraa Al Janabi
Gang Huang
Jackson Mittlesteadt
Michael Cheng
Atul Bhardwaj
Brandon L. Ashfeld
Kenneth R. Kao
Dean Y. Maeda
Xing Dai
Olaf Wiest
Brian S.J. Blagg
Xuemin Lu
Liang Cheng
Jun Wan
Xin Lu

Science ImmunologyVol. 8, NO. 8110 Mar 2023

Research Article

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity

by

Yongbin Choi
Jake N. Lichterman
Laura A. Coughlin
Nicole Poulides
Wenling Li
Priscilla Del Valle
Suzette N. Palmer
Shuheng Gan
Jiwoong Kim
Xiaowei Zhan
Yajing Gao
Bret M. Evers
Lora V. Hooper
Chandrashekhar Pasare
Andrew Y. Koh

Science ImmunologyVol. 8, NO. 8103 Mar 2023

Research Article

Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy

by

Noy Cohen Saban
Adam Yalin
Tomer Landsberger
Ran Salomon
Ajjai Alva
Tali Feferman
Ido Amit
Rony Dahan

Science ImmunologyVol. 8, NO. 8103 Mar 2023

Research Article

CD19 CAR antigen engagement mechanisms and affinity tuning

by

Changhao He
Jorge Mansilla-Soto
Nandish Khanra
Mohamad Hamieh
Victor Bustos
Alice J. Paquette
Andreina Garcia Angus
Derek M. Shore
William J. Rice
George Khelashvili
Michel Sadelain
Joel R. Meyerson

Science ImmunologyVol. 8, NO. 8103 Mar 2023

Research Article

Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages

by

Pauline Loos
Jérôme Baiwir
Céline Maquet
Justine Javaux
Rémy Sandor
François Lallemand
Thomas Marichal
Bénédicte Machiels
Laurent Gillet

Science ImmunologyVol. 8, NO. 8024 Feb 2023

Research Article

pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells

by

Patrick Fernandes Rodrigues
Athanasios Kouklas
Grozdan Cvijetic
Nicolas Bouladoux
Mladen Mitrovic
Jigar V. Desai
Djalma S. Lima-Junior
Michail S. Lionakis
Yasmine Belkaid
Robert Ivanek
Roxane Tussiwand

Science ImmunologyVol. 8, NO. 8024 Feb 2023

Research Article

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

by

Zhian Chen
Yanfang Cui
Yin Yao
Bo Liu
Joseph Yunis
Xin Gao
Naiqi Wang
Pablo F. Cañete
Zewen Kelvin Tuong
Hongjian Sun
Hao Wang
Siling Yang
Runli Wang
Yew Ann Leong
David Simon Davis
Jiahuan Qin
Kaili Liang
Jun Deng
Conan K. Wang
Yen-Hua Huang
Jonathan A. Roco
Sam Nettelfield
Huaming Zhu
Huajun Xu
Zhijia Yu
David Craik
Zheng Liu
Hai Qi
Christopher Parish
Di Yu

Science ImmunologyVol. 8, NO. 8017 Feb 2023

Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

Computational prediction of MHC anchor locations guides neoantigen identification and prioritization

Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation

Human T follicular helper clones seed the germinal center–resident regulatory pool

Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex

NK-like CD8⁺ γδ T cells are expanded in persistent Mycobacterium tuberculosis infection

DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification

The transcription factor Mef2d regulates B:T synapse–dependent GC-T_FH differentiation and IL-21–mediated humoral immunity

Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation

A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis

An XBP1s–PIM-2 positive feedback loop controls IL-15–mediated survival of natural killer cells

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity

Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy

CD19 CAR antigen engagement mechanisms and affinity tuning

Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages

pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation

Metabolic challenges and interventions in CAR T cell therapy

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

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