• Volume 380
  • Issue 6641
  • 14 Apr 2023

COVER This image depicts a variety of sperm trying to reach an oocyte. Some sperm are abnormal, and some of those are patched up—alluding to treatments that can overcome some types of sperm abnormalities to achieve viable offspring. Conversely, some healthy sperm are blocked by walls, which represent contraception. See the special section on human reproduction beginning on page 148.

Illustration: Sara Gironi Carnevale

Science Advances

  • Volume 9
  • Issue 15
  • 14 Apr 2023

ONLINE COVER An artist’s rendering of an optoelectronic memory device based on negative differential resistance (NDR) diodes and a micro-ring resonator. The coming end of Moore-like growth of computational power has increased focus on alternative computing architectures, such as electro-optical computing where light carries information in the circuit rather than electrons. Gherabli et al. demonstrate a fully CMOS-compatible electro-optical memory device, based on a new type of NDR-diode. The new diode is based on a horizontal PN-junction in silicon implemented into a photonic micro-ring resonator to create a bi-stable device with fully optical read-out in the telecom regime.

Credit: Christian Frydendahl

Science Immunology

  • Volume 8
  • Issue 82
  • Apr 2023

ONLINE COVER Intertwined Lineages. This month’s cover depicts two trees whose trunks have grown together and physically attached, a natural phenomenon known as inosculation. These trees represent two separate developmental lineages of T cells that can both yield T follicular regulatory (Tfr) cells. Using single-cell analysis techniques to study Tfr cells isolated from human tonsils, Le Coz et al. documented the presence of distinct Tfr subsets derived from either natural regulatory T cells or T follicular helper cells, each with distinct functional properties and localization within lymphoid tissues.

Credit: Ella Maru Studio

Science Robotics

  • Volume 8
  • Issue 76
  • Mar 2023

ONLINE COVER Robust robots. The ability of robots to endure severe damage, as well as offer the possibility for repair, can enable their deployment in challenging settings. Kim et al. have developed aerial robots that can endure several punctures while sustaining controlled flight. The dielectric elastomer actuators on the robots were also designed to be repairable by using laser ablation to isolate the defects and recover their performance. This month’s cover is a photograph of the aerial robot showing one dielectric elastomer actuator pierced with fiberglass needles.

Credit: Yi-Husan Hsiao and Sampson Wilcox

Science Signaling

  • Volume 16
  • Issue 780
  • 11 Apr 2023

ONLINE COVER This week, Gabriel and Streicher show in mice that opioids activate a pathway in the spine that inhibits their efficacy. This pathway is mediated by the kinase AMPK and can be blocked by HSP90 inhibitors. The image shows opioid-induced phosphorylation of ERK (green) in the spinal cord of mice that lack AMPK in certain neurons.

Image: Gabriel and Streicher/Science Signaling

Science Translational Medicine

  • Volume 15
  • Issue 691
  • 12 Apr 2023

ONLINE COVER A Cloak for Pancreatic Pseudoislets. The cover shows wild-type (top and left) and engineered hypoimmune (bottom and right) pancreatic pseudoislets derived from primary human pancreatic islet cells. The top and right pseudoislets were stained for somatostatin (blue), insulin (green), and glucagon (red). The bottom and left pseudoislets were stained for major histocompatibility complex (MHC) class I (red), CD47 (yellow), and nuclei (blue). Allogeneic pancreatic islet transplantation has been used to improve glycemic control in patients with diabetes but can provoke inflammatory reactions as well as allo- and autoimmunity, necessitating lifelong use of immunosuppressants by recipients. Hu et al. engineered allogeneic primary human pancreatic cells to lack MHC class I and II molecules, thereby hiding the cells from the recipient immune system. The engineered pancreatic cells were aggregated into pseudoislets which were then transplanted into immunocompetent, allogeneic, diabetic humanized mice. The hypoimmune pseudoislets survived and ameliorated diabetes in the mice without the need for treatment with immunosuppressants.

Credit: Hu et al./Science Translational Medicine

Science Partner Journals

The Open Access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and applied science.

The Open Access journal Plant Phenomics, published in association with NAU, publishes novel research that advances plant phenotyping and connects phenomics with other research domains.

The Open Access journal BMEF, published in association with SIBET-CAS, is a platform for the multidisciplinary community of biomedical engineering, publishing wide-ranging research in the field.

The Open Access journal BioDesign Research, published in association with NAU, publishes novel research in the interdisciplinary field of biosystems design.

The Open Access journal Advanced Devices & Instrumentation, published in association with BIACD, is a forum to promote breakthroughs and application advances at all levels of electronics and photonics.

The Open Access journal Cyborg and Bionic Systems, published in association with BIT, promotes the knowledge interchange and hybrid system codesign between living beings and robotic systems.

The Open Access journal Energy Material Advances, published in association with BIT, is an interdisciplinary platform for research in multiple fields from cutting-edge material to energy science.

The Open Access journal Space: Science & Technology, published in association with BIT, promotes the exploration and research of interdisciplinary sciences in the space field.

The Journal of Remote Sensing, an Open Access journal published in association with AIR-CAS, promotes the theory, science, and technology of remote sensing, as well as interdisciplinary research within earth and information science.

The Open Access journal Health Data Science, published in association with PKU, aims to advance the horizon of health data science through transdisciplinary learning, communication, and collaboration with health practitioners and policymakers.

The Open Access journal Ultrafast Science, published in association with XIOPM, publishes cutting-edge and emerging topics in ultrafast science with broad interest from scientific communities.

The Open Access journal Ocean-Land-Atmosphere Research (OLAR), published in association with SML-ZHUHAI, publishes technologically innovative research in marine, terrestrial, and atmospheric studies and the interactions among them.

The Open Access journal Intelligent Computing, published in affiliation with Zhejiang Lab, publishes the latest research outcomes and technological breakthroughs in intelligent computing.