Free Sample Articles from Science Immunology

Check out the Editors’ picks of COVID-19 papers published in Science Immunology! The Research Articles we’ve published to date cover a variety of topics including virus tropism and entry, the kinetics of T cell responses to SARS-CoV-2 epitopes, serology assays for diagnosis, and therapeutics to treat cytokine storm in hospitalized COVID-19 patients. The Focus commentaries discuss host-directed therapies for cytokine storm and use of SARS-CoV-2 antibody tests for seroepidemiology studies. Each Focus also features a customized figure crafted by the illustration team at AAAS in collaboration with the authors.

Research Articles and Reports

Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5
Alexander Muik et al.
Report | Science Immunology Date: 20-Sep-2022 DOI: 10.1126/sciimmunol.ade2283

An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion
Sai Luo et al.
Research Article | Science Immunology Date: 11-Aug-2022 DOI: 10.1126/sciimmunol.add5446

CD8 T Cells Contribute to Vaccine Protection Against SARS-CoV-2 in Macaques
Jinyan Liu et al.
Report | Science Immunology Date: 9-Aug-2022 DOI: 10.1126/sciimmunol.abq7647

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif
Yan Fang et al.
Research Article | Science Immunology Date: 4-Aug-2022 DOI: 10.1126/sciimmunol.abp9962

Respiratory mucosal immunity against SARS-CoV-2 following mRNA vaccination
Jinyi Tang et al.
Report | Science Immunology Date: 19-Jul-2022 DOI: 10.1126/sciimmunol.add4853

SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens
Laurent Bartolo et al.
Research Article | Science Immunology Date: 14-Jul-2022 DOI: 10.1126/sciimmunol.abn3127

IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2
Pavel A. Nikitin et al.
Research Article | Science Immunology Date: 30-Jun-2022 DOI: 10.1126/sciimmunol.abl9943

Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct
Anna Z. Mykytyn et al.
Report | Science Immunology Date: 23-Jun-2022 DOI: 10.1126/sciimmunol.abq4450

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Paul Bastard et al.
Report | Science Immunology Date: 14-Jun-2022 DOI: 10.1126/sciimmunol.abp8966

Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes
Jasmin Quandt et al.
Research Article | Science Immunology Date: 2-Jun-2022 DOI: 10.1126/sciimmunol.abq2427

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Rajendra Karki et al.
Research Article | Science Immunology Date: 19-May-2022 DOI: 10.1126/sciimmunol.abo6294

Immune recall improves antibody durability and breadth to SARS-CoV-2 variants
Yuezhou Chen et al.
Research Article | Science Immunology Date: 12-May-2022 DOI: 10.1126/sciimmunol.abp8328

Recall of pre-existing cross-reactive B cell memory following Omicron BA.1 breakthrough infection
Chengzi I. Kaku et al.
Report | Science Immunology Date: 12-May-2022 DOI: 10.1126/sciimmunol.abq3511

Antibodies induced by ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1
Ian W. Windsor et al.
Report | Science Immunology Date: 10-May-2022 DOI: 10.1126/sciimmunol.abo3425

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
Wenjuan Du et al.
Research Article | Science Immunology Date: 26-Apr-2022 DOI: 10.1126/sciimmunol.abp9312

SARS-CoV-2 epitope-specific CD4+ memory T cell responses across COVID-19 disease severity and antibody durability
Ryan W. Nelson et al.
Research Article | Science Immunology Date: 21-Apr-2022 DOI: 10.1126/sciimmunol.abl9464

A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 delta infection
Nanda Kishore Routhu et al.
Research Article | Science Immunology Date: 31-Mar-2022 DOI: 10.1126/sciimmunol.abo0226

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues
Christine E. Nelson et al.
Research Article | Science Immunology Date: 10-Mar-2022 DOI: 10.1126/sciimmunol.abo0535

Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients
Corine H. GeurtsvanKessel et al.
Research Article | Science Immunology Date: 3-Feb-2022 DOI: 10.1126/sciimmunol.abo2202

SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine
Ryutaro Kotaki et al.
Report | Science Immunology Date: 3-Feb-2022 DOI: 10.1126/sciimmunol.abn8590

Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants
Timothy A. Bates et al.
Research Article | Science Immunology Date: 15-Jan-2022 DOI: 10.1126/sciimmunol.abn8014

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
Jennifer S. Chen et al.
Research Article | Science Immunology Date: 16-Dec-2021 DOI: 10.1126/sciimmunol.abl5652

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
Valeria Fumagalli et al.
Report | Science Immunology Date: 23-Nov-2021 DOI: 10.1126/sciimmunol.abl9929

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
Joshua M. Francis et al.
Research Article | Science Immunology Date: 18-Nov-2021 DOI: 10.1126/sciimmunol.abk3070

BNT162b2 vaccination induces durable SARS-CoV-2 specific T cells with a stem cell memory phenotype
Gisella Guerrera et al.
Research Article | Science Immunology Date: 2-Nov-2021 DOI: 10.1126/sciimmunol.abl5344

Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission
Shu Horiuchi et al.
Research Article | Science Immunology Date: 26-Oct-2021 DOI: 10.1126/sciimmunol.abm3131

Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity
Sarah Sanchez et al.
Research Article | Science Immunology Date: 14-Oct-2021 DOI: 10.1126/sciimmunol.abi8635

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses
Jared Feldman et al.
Research Article | Science Immunology Date: 14-Oct-2021 DOI: 10.1126/sciimmunol.abl5842

SARS-CoV-2 infection generates tissue-localized immunological memory in humans
Maya M. L. Poon et al.
Research Article | Science Immunology Date: 07-Oct-2021 DOI: 10.1126/sciimmunol.abl9105

Immune signatures underlying post-acute COVID-19 lung sequelae
I. S. Cheon et al.
Research Article | Science Immunology Date: 30-Sep-2021 DOI: 10.1126/sciimmunol.abk1741

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue
Julia Niessl et al.
Report | Science Immunology Date: 14-Sep-2021 DOI: 10.1126/sciimmunol.abk0894

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19
Paulina Kaplonek et al.
Report | Science Immunology Date: 9-Sep-2021 DOI: 10.1126/sciimmunol.abj2901

Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2
Benjamin Israelow et al.
Research Article | Science Immunology Date: 2-Sep-2021 DOI: 10.1126/sciimmunol.abl4509

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Paul Bastard et al.
Research Article | Science Immunology Date: 19-Aug-2021 DOI: 10.1126/sciimmunol.abl4340

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
Takaki Asano et al.
Research Article | Science Immunology Date: 19-Aug-2021 DOI: 10.1126/sciimmunol.abl4348

Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients
Samuele Notarbartolo et al.
Research Resource | Science Immunology  Date: 10-Aug-2021 DOI: 10.1126/sciimmunol.abg5021

Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
Nadine Rouphael et al.
Research Resource | Science Immunology Date: 10-Aug-2021 DOI: 10.1126/sciimmunol.abf3733

Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers
Shelley Klompus et al.
Research Article | Science Immunology Date: 29-Jul-2021 DOI: 10.1126/sciimmunol.abe9950

A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates
Maria Pino et al.
Research Article | Science Immunology Date: 15-Jul-2021 DOI: 10.1126/sciimmunol.abh3634

CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients
Vamsee Mallajosyula et al.
Research Article | Science Immunology Date: 1-Jul-2021 DOI: 10.1126/sciimmunol.abg5669

Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients
Hector Rincon-Arevalo et al.
Research Article | Science Immunology Date: 15-Jun-2021 DOI: 10.1126/sciimmunol.abj1031

SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques
Carolina Garrido et al.
Research Article | Science Immunology Date: 15-Jun-2021 DOI: 10.1126/sciimmunol.abj3684

Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem Inflammatory Syndrome in Children
Marion Moreews et al.
Research Article | Science Immunology Date: 25-May-2021 DOI: 10.1126/sciimmunol.abh1516

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees
Daryl Geers et al.
Research Article | Science Immunology Date: 25-May-2021 DOI: 10.1126/sciimmunol.abj1750

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
Fiachra Humphries et al.
Research Article | Science Immunology Date: 18-May-2021 DOI: 10.1126/sciimmunol.abi9002

Pharmacological activation of STING blocks SARS-CoV-2 infection
Minghua Li et al.
Research Article | Science Immunology Date: 18-May-2021 DOI: 10.1126/sciimmunol.abi9007

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Lina Ma et al.
Research Article | Science Immunology Date: 13-May-2021 DOI: 10.1126/sciimmunol.abh2259

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination
Rishi R. Goel et al.
Research Article | Science Immunology Date: 15-Apr-2021 DOI: 10.1126/sciimmunol.abi6950

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
Sunil Kumar Saini et al.
Research Article | Science Immunology Date: 14-Apr-2021 DOI: 10.1126/sciimmunol.abf7550

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Bingyu Yan et al.
Research Article | Science Immunology Date: 7-Apr-2021 DOI: 10.1126/sciimmunol.abg0833

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19
Ryan S. Thwaites et al.
Research Article | Science Immunology Date: 10-Mar-2021 DOI: 10.1126/sciimmunol.abg9873

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
Benedikt Agerer et al.
Research Article | Science Immunology Date: 4-Mar-2021 DOI: 10.1126/sciimmunol.abg6461

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19
Laura A. Vella et al.
Research Article | Science Immunology Date: 2-Mar-2021 DOI: 10.1126/sciimmunol.abf7570

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Yu Zhao et al.
Research Article | Science Immunology Date: 23-Feb-2021 DOI: 10.1126/sciimmunol.abf6692

Prolonged evolution of the human B cell response to SARS-CoV-2 infection
Mrunal Sakharkar et al.
Research Article | Science Immunology Date: 23-Feb-2021 DOI: 10.1126/sciimmunol.abg6916

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells
Anthony Kusnadi et al.
Research Article | Science Immunology Date: 21-Jan-2021 DOI: 10.1126/sciimmunol.abe4782

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection
Catherine J. Reynolds et al.
Research Article | Science Immunology Date: 23-Dec-2020 DOI: 10.1126/sciimmunol.abf3698

Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
Gemma E. Hartley et al.
Report | Science Immunology Date: 22-Dec-2020 DOI: 10.1126/sciimmunol.abf8891

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome
Katharina Röltgen et al.
Research Article | Science Immunology Date: 7-Dec-2020 DOI: 10.1126/sciimmunol.abe0240

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
Baweleta Isho et al.
Research Article | Science Immunology Date: 8-Oct-2020 DOI: 10.1126/sciimmunol.abe5511

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients
Anita S. Iyer et al.
Report | Science Immunology Date: 8-Oct-2020 DOI: 10.1126/sciimmunol.abe0367

MAIT cell activation and dynamics associated with COVID-19 disease severity
Tiphaine Parrot et al.
Report | Science Immunology Date: 28-Sep-2020 DOI: 10.1126/sciimmunol.abe1670

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
Elizabeth R. Mann et al.
Research Article | Science Immunology Date: 17-Sep-2020 DOI: 10.1126/sciimmunol.abd6197

Natural killer cell immunotypes related to COVID-19 disease severity
Christopher Maucourant et al.
Research Article | Science Immunology Date: 21-Aug-2020 DOI: 10.1126/sciimmunol.abd6832

SARS-CoV-2 seroprevalence among parturient women in Philadelphia
Dustin D. Flannery et al.
Report | Science Immunology Date: 29-Jul-2020 DOI: 10.1126/sciimmunol.abd5709

Comprehensive mapping of immune perturbations associated with severe COVID-19
Leticia Kuri-Cervantes et al.
Research Article | Science Immunology Date: 15-Jul-2020 DOI: 10.1126/sciimmunol.abd7114

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Jeong Seok Lee et al.
Research Article | Science Immunology Date: 10-Jul-2020 DOI: 10.1126/sciimmunol.abd1554

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome
Daniela Weiskopf et al.
Research Article | Science Immunology Date: 26-Jun-2020 DOI: 10.1126/sciimmunol.abd2071

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients
Lakshmanane Premkumar et al.
Research Article | Science Immunology Date: 11-Jun-2020 DOI: 10.1126/sciimmunol.abc8413

Inhibition of Bruton tyrosine kinase in patients with severe COVID-19
Mark Roschewski et al.
Research Article | Science Immunology Date: 5-Jun-2020 DOI: 10.1126/sciimmunol.abd0110

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
Ruochen Zang et al.
Research Article | Science Immunology Date: 13-May-2020 DOI: 10.1126/sciimmunol.abc3582


Innate immunological pathways in COVID-19 pathogenesis
Søren R. Paludan and Trine H. Mogensen
Review | Science Immunology Date: 7-Jan-2022 DOI: 10.1126/sciimmunol.abm5505

Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection
Michael J. Christie et al.
Review | Science Immunology Date: 17-Sep-2021 DOI: 10.1126/sciimmunol.abd0205

Focus and Perspective Commentaries & Editorials

Operation Nasal Vaccine—Lightning speed to counter COVID-19
Eric J. Topol and Akiko Iwasaki
Editorial | Science Immunology Date: 21-Jul-2022 DOI: 10.1126/sciimmunol.add9947

Immune memory to SARS-CoV-2 Omicron BA.1 breakthrough infections: To change the vaccine or not?
Menno C. van Zelm et al.
Focus | Science Immunology Date: 2-Jun-2022 DOI: 10.1126/sciimmunol.abq5901

Understanding T-cell responses to COVID-19 is essential for informing public health strategies
Santosha Vardhana et al.
Viewpoint | Science Immunology Date: 24-Mar-2022 DOI: 10.1126/sciimmunol.abo1303

Implications of defective immune responses in SARS-CoV-2 vaccinated organ transplant recipients
Peter S. Heeger et al.
Editorial | Science Immunology Date: 01-Jul-2021 DOI: 10.1126/sciimmunol.abj6513

COVID-19 vaccine side effects: The positives about feeling bad
Jonathan Sprent and Cecile King
Focus | Science Immunology Date: 22-Jun-2021 DOI: 10.1126/sciimmunol.abj9256

Complement control for COVID-19
Markus Bosmann
Focus | Science Immunology Date: 25-May-2021 DOI: 10.1126/sciimmunol.abj1014

The known unknowns of T cell immunity to COVID-19
Annika C. Karlsson et al.
Perspective | Science Immunology Date: 18-Nov-2020 DOI: 10.1126/sciimmunol.abe8063

SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection
Daniel M. Altmann and Rosemary J. Boyton
Perspective | Science Immunology Date: 17-Jul-2020 DOI: 10.1126/sciimmunol.abd6160

Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward
Juliet E. Bryant et al.
Focus | Science Immunology Date: 19-May-2020 DOI: 10.1126/sciimmunol.abc6347

HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19
Francesca Romana Spinelli et al.
Focus | Science Immunology Date: 8-May-2020 DOI: 10.1126/sciimmunol.abc5367

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Check out the 2021 Editors’ picks of top articles published in Science Immunology this year!

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