Contents | Science Signaling 16, 780

ONLINE COVER This week, Gabriel and Streicher show in mice that opioids activate a pathway in the spine that inhibits their efficacy. This pathway is mediated by the kinase AMPK and can be blocked by HSP90 inhibitors. The image shows opioid-induced phosphorylation of ERK (green) in the spinal cord of mice that lack AMPK in certain neurons.

Image: Gabriel and Streicher/Science Signaling

Science Signaling

Volume 16|
Issue 780|
11 Apr 2023

Image: Gabriel and Streicher/Science Signaling

Research Articles

SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency

BY
- Laurent Schmied
- Thuy T. Luu
- Jonas N. Søndergaard
- Sophia H. Hald
- Stephan Meinke
- Dara K. Mohammad
- Sunitha B. Singh
- Corinna Mayer
- Giovanna Perinetti Casoni
- Michael Chrobok
- Heinrich Schlums
- Giorgia Rota
- Hieu M. Truong
- Lisa S. Westerberg
- Greta Guarda
- Evren Alici
- Arnika K. Wagner
- Nadir Kadri
- Yenan T. Bryceson
- Mezida B. Saeed
- Petter Höglund
11 Apr 2023
NO ACCESS

The spatial patterning of the tyrosine phosphatase SHP-1 in mouse NK cells may determine self-tolerance.

Abstract

Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating receptors, recognizing products from tumors or viruses, and inhibitory receptors (such as KIR/Ly49), which recognize ...

HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop

BY
- Katherin A. Gabriel
- John M. Streicher
11 Apr 2023
Free

The activity of the chaperone HSP90 and the kinase AMPK in the spine limits opioid efficacy.

Abstract

Opioids and other agonists of the μ-opioid receptor are effective at managing acute pain, but their chronic use can lead to tolerance that limits their efficacy. We previously reported that inhibiting the chaperone protein HSP90 in the spinal cords of ...