Contents | Science Immunology 8, 82

ONLINE COVER Intertwined Lineages. This month’s cover depicts two trees whose trunks have grown together and physically attached, a natural phenomenon known as inosculation. These trees represent two separate developmental lineages of T cells that can both yield T follicular regulatory (Tfr) cells. Using single-cell analysis techniques to study Tfr cells isolated from human tonsils, Le Coz et al. documented the presence of distinct Tfr subsets derived from either natural regulatory T cells or T follicular helper cells, each with distinct functional properties and localization within lymphoid tissues.

Credit: Ella Maru Studio

Science Immunology

Volume 8|
Issue 82|
Apr 2023

Credit: Ella Maru Studio

Focus

The expanding family of T follicular regulatory cells

BY
- Luis Graca
- Johanne Jacobsen
- Saumya Kumar
07 Apr 2023
NO ACCESS

The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses.

Abstract

The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses in providing optimal antibody production and preventing events leading to autoimmunity (see the related Research Article ...

Review

Metabolic challenges and interventions in CAR T cell therapy

BY
- Jhan-Jie Peng
- Limei Wang
- Zhiyu Li
- Cheng-Lung Ku
- Ping-Chih Ho
14 Apr 2023
NO ACCESS

Recent advances in CAR T cell manufacturing have opened new avenues for optimizing their metabolic programming in order to enhance antitumor activity.

Abstract

Chimeric antigen receptor (CAR) T cells have achieved true clinical success in treating hematological malignancy patients, laying the foundation of CAR T cells as a new pillar of cancer therapy. Although these promising effects have generated strong ...

Research Articles

Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation

BY
- Zhilin Li
- Salli Antila
- Harri Nurmi
- Dmitri Chilov
- Emilia A. Korhonen
- Shentong Fang
- Sinem Karaman
- Britta Engelhardt
- Kari Alitalo
14 Apr 2023
NO ACCESS

Intact dural lymphatic vessels are not essential for autoimmune neuroinflammation.

Abstract

The recent discovery of lymphatic vessels (LVs) in the dura mater, the outermost layer of meninges around the central nervous system (CNS), has opened a possibility for the development of alternative therapeutics for CNS disorders. The vascular ...

Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation

BY
- Thomas Fabre
- Alexander M. S. Barron
- Stephen M. Christensen
- Shoh Asano
- Kathryn Bound
- Matthew P. Lech
- Marc H. Wadsworth, II
- Xiao Chen
- Chang Wang
- Ju Wang
- James McMahon
- Franklin Schlerman
- Alexis White
- Kellie M. Kravarik
- Andrew J. Fisher
- Lee A. Borthwick
- Kevin M. Hart
- Neil C. Henderson
- Thomas A. Wynn
- Ken Dower
07 Apr 2023
NO ACCESS

A five-marker signature identifies scar-associated macrophages that differentiate in response to GM-CSF, IL-17A, and TGF-β across species and tissues.

Abstract

Macrophages are central orchestrators of the tissue response to injury, with distinct macrophage activation states playing key roles in fibrosis progression and resolution. Identifying key macrophage populations found in human fibrotic tissues could lead ...

Human T follicular helper clones seed the germinal center–resident regulatory pool

BY
- Carole Le Coz
- Derek A. Oldridge
- Ramin S. Herati
- Nina De Luna
- James Garifallou
- Emylette Cruz Cabrera
- Jonathan P. Belman
- Dana Pueschl
- Luisa V. Silva
- Ainsley V. C. Knox
- Whitney Reid
- Samuel Yoon
- Karen B. Zur
- Steven D. Handler
- Hakon Hakonarson
- E. John Wherry
- Michael Gonzalez
- Neil Romberg
07 Apr 2023
Free

The origin of human tonsillar T follicular regulatory cells, from T_reg or Tfh lineages, predicts TCR repertoire, location, and function.

Abstract

The mechanisms by which FOXP3⁺ T follicular regulatory (Tfr) cells simultaneously steer antibody formation toward microbe or vaccine recognition and away from self-reactivity remain incompletely understood. To explore underappreciated heterogeneity in ...

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

BY
- Bibo Zhu
- Xiaoqin Wei
- Harish Narasimhan
- Wei Qian
- Ruixuan Zhang
- In Su Cheon
- Yue Wu
- Chaofan Li
- Russell G. Jones
- Mark H. Kaplan
- Robert A. Vassallo
- Thomas J. Braciale
- Lindsay Somerville
- Jerry R. Colca
- Akhilesh Pandey
- Patrick E. H. Jackson
- Barbara J. Mann
- Connie M. Krawczyk
- Jeffrey M. Sturek
- Jie Sun
14 Apr 2023
Open Access

Inhibiting mitochondrial pyruvate carrier concurrently promotes host metabolic health and reduces pulmonary inflammation in COVID-19.

Abstract

The relationship between diabetes and coronavirus disease 2019 (COVID-19) is bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) are predisposed to severe COVID-19, severe acute respiratory syndrome coronavirus ...

Research Resource

Computational prediction of MHC anchor locations guides neoantigen identification and prioritization

BY
- Huiming Xia
- Joshua McMichael
- Michelle Becker-Hapak
- Onyinyechi C. Onyeador
- Rico Buchli
- Ethan McClain
- Patrick Pence
- Suangson Supabphol
- Megan M. Richters
- Anamika Basu
- Cody A. Ramirez
- Cristina Puig-Saus
- Kelsy C. Cotto
- Sharon L. Freshour
- Jasreet Hundal
- Susanna Kiwala
- S. Peter Goedegebuure
- Tanner M. Johanns
- Gavin P. Dunn
- Antoni Ribas
- Christopher A. Miller
- William E. Gillanders
- Todd A. Fehniger
- Obi L. Griffith
- Malachi Griffith
07 Apr 2023
NO ACCESS

Neoantigen prediction accuracy is improved by considering where mutations are relative to patient MHC allele-specific anchor locations.

Abstract

Neoantigens are tumor-specific peptide sequences resulting from sources such as somatic DNA mutations. Upon loading onto major histocompatibility complex (MHC) molecules, they can trigger recognition by T cells. Accurate neoantigen identification is thus ...