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ONLINE COVER Intertwined Lineages. This month’s cover depicts two trees whose trunks have grown together and physically attached, a natural phenomenon known as inosculation. These trees represent two separate developmental lineages of T cells that can both yield T follicular regulatory (Tfr) cells. Using single-cell analysis techniques to study Tfr cells isolated from human tonsils, Le Coz et al. documented the presence of distinct Tfr subsets derived from either natural regulatory T cells or T follicular helper cells, each with distinct functional properties and localization within lymphoid tissues.

Credit: Ella Maru Studio

Science Immunology

  • Volume 8|
  • Issue 82|
  • Apr 2023

ONLINE COVER Intertwined Lineages. This month’s cover depicts two trees whose trunks have grown together and physically attached, a natural phenomenon known as inosculation. These trees represent two separate developmental lineages of T cells that can both yield T follicular regulatory (Tfr) cells. Using single-cell analysis techniques to study Tfr cells isolated from human tonsils, Le Coz et al. documented the presence of distinct Tfr subsets derived from either natural regulatory T cells or T follicular helper cells, each with distinct functional properties and localization within lymphoid tissues.

Credit: Ella Maru Studio

Focus

  • BY
    • Luis Graca
    • Johanne Jacobsen
    • Saumya Kumar
  • NO ACCESS
The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses.

Review

  • BY
    • Jhan-Jie Peng
    • Limei Wang
    • Zhiyu Li
    • Cheng-Lung Ku
    • Ping-Chih Ho
  • NO ACCESS
Recent advances in CAR T cell manufacturing have opened new avenues for optimizing their metabolic programming in order to enhance antitumor activity.

Research Articles

  • BY
    • Zhilin Li
    • Salli Antila
    • Harri Nurmi
    • Dmitri Chilov
    • Emilia A. Korhonen
    • Shentong Fang
    • Sinem Karaman
    • Britta Engelhardt
    • Kari Alitalo
  • NO ACCESS
Intact dural lymphatic vessels are not essential for autoimmune neuroinflammation.
  • BY
    • Thomas Fabre
    • Alexander M. S. Barron
    • Stephen M. Christensen
    • Shoh Asano
    • Kathryn Bound
    • Matthew P. Lech
    • Marc H. Wadsworth, II
    • Xiao Chen
    • Chang Wang
    • Ju Wang
    • James McMahon
    • Franklin Schlerman
    • Alexis White
    • Kellie M. Kravarik
    • Andrew J. Fisher
    • Lee A. Borthwick
    • Kevin M. Hart
    • Neil C. Henderson
    • Thomas A. Wynn
    • Ken Dower
  • NO ACCESS
A five-marker signature identifies scar-associated macrophages that differentiate in response to GM-CSF, IL-17A, and TGF-β across species and tissues.
  • BY
    • Carole Le Coz
    • Derek A. Oldridge
    • Ramin S. Herati
    • Nina De Luna
    • James Garifallou
    • Emylette Cruz Cabrera
    • Jonathan P. Belman
    • Dana Pueschl
    • Luisa V. Silva
    • Ainsley V. C. Knox
    • Whitney Reid
    • Samuel Yoon
    • Karen B. Zur
    • Steven D. Handler
    • Hakon Hakonarson
    • E. John Wherry
    • Michael Gonzalez
    • Neil Romberg
  • Free
The origin of human tonsillar T follicular regulatory cells, from Treg or Tfh lineages, predicts TCR repertoire, location, and function.
  • BY
    • Bibo Zhu
    • Xiaoqin Wei
    • Harish Narasimhan
    • Wei Qian
    • Ruixuan Zhang
    • In Su Cheon
    • Yue Wu
    • Chaofan Li
    • Russell G. Jones
    • Mark H. Kaplan
    • Robert A. Vassallo
    • Thomas J. Braciale
    • Lindsay Somerville
    • Jerry R. Colca
    • Akhilesh Pandey
    • Patrick E. H. Jackson
    • Barbara J. Mann
    • Connie M. Krawczyk
    • Jeffrey M. Sturek
    • Jie Sun
  • Open Access
Inhibiting mitochondrial pyruvate carrier concurrently promotes host metabolic health and reduces pulmonary inflammation in COVID-19.

Research Resource

  • BY
    • Huiming Xia
    • Joshua McMichael
    • Michelle Becker-Hapak
    • Onyinyechi C. Onyeador
    • Rico Buchli
    • Ethan McClain
    • Patrick Pence
    • Suangson Supabphol
    • Megan M. Richters
    • Anamika Basu
    • Cody A. Ramirez
    • Cristina Puig-Saus
    • Kelsy C. Cotto
    • Sharon L. Freshour
    • Jasreet Hundal
    • Susanna Kiwala
    • S. Peter Goedegebuure
    • Tanner M. Johanns
    • Gavin P. Dunn
    • Antoni Ribas
    • Christopher A. Miller
    • William E. Gillanders
    • Todd A. Fehniger
    • Obi L. Griffith
    • Malachi Griffith
  • NO ACCESS
Neoantigen prediction accuracy is improved by considering where mutations are relative to patient MHC allele-specific anchor locations.

Editors' Choice

  • BY
    • Ángel Garza Reyna
    • Gabriel K. Griffin
  • Free
TET2 disruption makes CAR-T cells work better, but not without a cost.
  • BY
    • Asha Pillai
  • Free
CD169+ macrophage–intrinsic IL-10 production mitigates mortality from sepsis.

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