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ONLINE COVER Tumor-infiltrating Lymphocytes on JET Patrol. This month’s cover depicts T lymphocytes specific for tumor neoantigens near a cancer cell (yellow) displaying neoantigen peptides on a subset of its cell-surface MHC molecules. JETs (Junctions between Exons and Transposable elements) are a new class of cancer-associated neoantigens made by tumor cells as a result of noncanonical mRNA splicing linking exons to transcripts from transposable elements. Merlotti et al. identified recurrent JETs in human lung tumors and the presence of CD8+ T cells specific for JET-encoded epitopes in cancer patients. In a companion paper, Burbage et al. used mouse models to demonstrate that tumor-specific expression of JETs is under epigenetic control.

Credit: Alexis Finkbeiner/Mnemo Therapeutics

Science Immunology

  • Volume 8|
  • Issue 80|
  • Feb 2023

ONLINE COVER Tumor-infiltrating Lymphocytes on JET Patrol. This month’s cover depicts T lymphocytes specific for tumor neoantigens near a cancer cell (yellow) displaying neoantigen peptides on a subset of its cell-surface MHC molecules. JETs (Junctions between Exons and Transposable elements) are a new class of cancer-associated neoantigens made by tumor cells as a result of noncanonical mRNA splicing linking exons to transcripts from transposable elements. Merlotti et al. identified recurrent JETs in human lung tumors and the presence of CD8+ T cells specific for JET-encoded epitopes in cancer patients. In a companion paper, Burbage et al. used mouse models to demonstrate that tumor-specific expression of JETs is under epigenetic control.

Credit: Alexis Finkbeiner/Mnemo Therapeutics

Research Articles

  • BY
    • Pauline Loos
    • Jérôme Baiwir
    • Céline Maquet
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    • Rémy Sandor
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    • Bénédicte Machiels
    • Laurent Gillet
  • NO ACCESS
Gammaherpesvirus infection subverts lung ILC2s thereby promoting alveolar macrophage differentiation with reduced type 2 functions.
  • BY
    • Antonela Merlotti
    • Benjamin Sadacca
    • Yago A. Arribas
    • Mercia Ngoma
    • Marianne Burbage
    • Christel Goudot
    • Alexandre Houy
    • Ares Rocañín-Arjó
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    • Agathe Seguin-Givelet
    • Marine Lefevre
    • Sandrine Heurtebise-Chrétien
    • Blandine Baudon
    • Giacomo Oliveira
    • Damarys Loew
    • Montserrat Carrascal
    • Catherine J. Wu
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    • Marc-Henri Stern
    • Nicolas Girard
    • Joshua J. Waterfall
    • Sebastian Amigorena
  • NO ACCESS
Tumor specific transposable elements-exon splicing junctions generate immunogenic HLA-I–bound peptides in NSCLC patients.
  • BY
    • Marianne Burbage
    • Ares Rocañín-Arjó
    • Blandine Baudon
    • Yago A. Arribas
    • Antonela Merlotti
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    • Sandrine Heurtebise-Chrétien
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    • Alexandre Houy
    • Nina Burgdorf
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    • Marine Gros
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    • Montserrat Carrascal
    • Andrea Garmilla
    • Mylène Bohec
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    • Damarys Loew
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    • Christel Goudot
    • Sebastian Amigorena
  • NO ACCESS
Noncanonical splice junctions between exons and transposable elements are a source of epigenetically-regulated tumor antigens.
  • BY
    • Sanjaya K. Sahu
    • Ayşe N. Ozantürk
    • Devesha H. Kulkarni
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    • Angel Lu
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    • Ja’Nia McPhatter
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    • Xiaobo Wu
    • Andrew E. Gelman
    • Steven L. Brody
    • John P. Atkinson
    • Hrishikesh S. Kulkarni
  • NO ACCESS
Lung-derived C3 mitigates bacterial pneumonia suggesting a cytoprotective role at barrier surfaces independent of circulating C3.
  • BY
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    • Clement Conil
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    • Anna-Lena Neehus
    • Marie Materna
    • Ji Eun Han
    • Jessica Peel
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    • Marc Weisshaar
    • Sandra Jovic
    • Paul Bastard
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    • Tom Le Voyer
    • Peng Zhang
    • Majistor Raj Luxman Maglorius Renkilaraj
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    • Yoann Seeleuthner
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  • NO ACCESS
IL-23 signaling is required for baseline and IL-23-inducible IFN-γ immunity in both Vδ2+ γδT and MAIT cells.
  • BY
    • Zhian Chen
    • Yanfang Cui
    • Yin Yao
    • Bo Liu
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    • Xin Gao
    • Naiqi Wang
    • Pablo F. Cañete
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    • Hongjian Sun
    • Hao Wang
    • Siling Yang
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    • Yew Ann Leong
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    • Jun Deng
    • Conan K. Wang
    • Yen-Hua Huang
    • Jonathan A. Roco
    • Sam Nettelfield
    • Huaming Zhu
    • Huajun Xu
    • Zhijia Yu
    • David Craik
    • Zheng Liu
    • Hai Qi
    • Christopher Parish
    • Di Yu
  • NO ACCESS
Low sulfation of heparan sulfate in BGC cells supports the desensitization to IL-21 and stringent selection for ASC differentiation.
  • BY
    • Wei Luo
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    • Rebecca A. Elsner
    • Shuchi Smita
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    • Derrick Callahan
    • Shuxian Wu
    • Maria Chikina
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  • NO ACCESS
Reprogrammed IL-21R signaling in GC B cells, in synergy with CD40 signaling, regulates GC B cell positive selection and differentiation.
  • BY
    • Patrick Fernandes Rodrigues
    • Athanasios Kouklas
    • Grozdan Cvijetic
    • Nicolas Bouladoux
    • Mladen Mitrovic
    • Jigar V. Desai
    • Djalma S. Lima-Junior
    • Michail S. Lionakis
    • Yasmine Belkaid
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  • NO ACCESS
pDC-like cells are circulating precursors for cDC2 that control differentiation of homeostatic CD4+ TH17 cells.
  • BY
    • Zheng Gong
    • Qing Li
    • Jiayuan Shi
    • Peishan Li
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    • Guangwen Ren
  • NO ACCESS
Lung-resident mesenchymal cells reprogram neutrophils to be immunosuppressive cells that facilitate lung metastasis of breast cancer.
  • BY
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    • Kai-Hui Yao
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    • Magnus A. G. Hoffmann
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    • Michel C. Nussenzweig
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  • NO ACCESS
IOMA germline–targeting Env immunogens induce CD4 binding site–specific broadly neutralizing antibodies against HIV in multiple animal models.

Editor's choice

  • BY
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  • NO ACCESS
Iterative acute stimulations can maintain CD8 T cells for longer than their organismal lifespan.

Editors' Choice

  • BY
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TCR sequencing and analysis of predicted CDR3 structures were used to identify TCR similarity groups and the M. Tuberculosis antigens they recognize that associate with infection control or progression.

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