ONLINE COVER Tumor-infiltrating Lymphocytes on JET Patrol. This month’s cover depicts T lymphocytes specific for tumor neoantigens near a cancer cell (yellow) displaying neoantigen peptides on a subset of its cell-surface MHC molecules. JETs (Junctions between Exons and Transposable elements) are a new class of cancer-associated neoantigens made by tumor cells as a result of noncanonical mRNA splicing linking exons to transcripts from transposable elements. Merlotti et al. identified recurrent JETs in human lung tumors and the presence of CD8+ T cells specific for JET-encoded epitopes in cancer patients. In a companion paper, Burbage et al. used mouse models to demonstrate that tumor-specific expression of JETs is under epigenetic control.
Credit: Alexis Finkbeiner/Mnemo TherapeuticsONLINE COVER Tumor-infiltrating Lymphocytes on JET Patrol. This month’s cover depicts T lymphocytes specific for tumor neoantigens near a cancer cell (yellow) displaying neoantigen peptides on a subset of its cell-surface MHC molecules. JETs (Junctions between Exons and Transposable elements) are a new class of cancer-associated neoantigens made by tumor cells as a result of noncanonical mRNA splicing linking exons to transcripts from transposable elements. Merlotti et al. identified recurrent JETs in human lung tumors and the presence of CD8+ T cells specific for JET-encoded epitopes in cancer patients. In a companion paper, Burbage et al. used mouse models to demonstrate that tumor-specific expression of JETs is under epigenetic control.
Credit: Alexis Finkbeiner/Mnemo Therapeutics