Contents | Science Immunology 7, 77

ONLINE COVER Rejuvenation Potential of T_RM Subsets. This month’s cover depicts a “fountain of youth” from which new tissue resident memory T cells (T_RM) are emerging after a secondary infectious challenge. Newly formed CD103^– T_RM (blue) and CD103⁺ T_RM (red) are derived from proliferating, CD103^– precursor cells and join the pool of preexisting CD103⁺ T_RM (gray) that lack this restorative capacity. This model for T_RM replenishment is supported by new fate-mapping mouse models described in separate papers by von Hoesslin and Kuhlmann et al. and Fung et al. that are discussed in a Focus by Jensen and Farber.

Credit: Ella Maru Studio

Science Immunology

Volume 7|
Issue 77|
Nov 2022

Credit: Ella Maru Studio

Focus

Gutsy memory T cells stand their ground against pathogens

BY
- Isaac J. Jensen
- Donna L. Farber
04 Nov 2022
NO ACCESS

Elegant fate-mapping models to label intestinal tissue-resident memory CD8⁺ T (T_RM) cells demonstrate retention and lack of expansion of CD103⁺ T_RM cells, whereas intestinal CD103⁻ memory cells expand, forming both new tissue-localized CD103⁺ and CD103⁻ T_...

Abstract

Research Articles

A central role for STAT5 in the transcriptional programing of T helper cell metabolism

BY
- Alejandro V. Villarino
- Arian DJ Laurence
- Fred P. Davis
- Luis Nivelo
- Stephen R. Brooks
- Hong-Wei Sun
- Kan Jiang
- Behdad Afzali
- Daniela Frasca
- Lothar Hennighausen
- Yuka Kanno
- John J. O’Shea
25 Nov 2022
NO ACCESS

STAT5 is a master regulator of T cell metabolism.

Abstract

Activated lymphocytes adapt their metabolism to meet the energetic and biosynthetic demands imposed by rapid growth and proliferation. Common gamma chain (cγ) family cytokines are central to these processes, but the role of downstream signal transducer ...

CD103 fate mapping reveals that intestinal CD103⁻ tissue-resident memory T cells are the primary responders to secondary infection

BY
- Helen Y. Fung
- Matthew Teryek
- Alexander D. Lemenze
- Tessa Bergsbaken
04 Nov 2022
NO ACCESS

CD103^– T_rm cells display enhanced TCR-dependent reactivation, proliferation, and effector function when compared to CD103⁺ T_rm cells.

Abstract

Tissue-resident memory T (T_RM) cells remain poised in the tissue and mediate robust protection from secondary infection. T_RM cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of ...

Oxidized thioredoxin-1 restrains the NLRP1 inflammasome

BY
- Daniel P. Ball
- Lydia P. Tsamouri
- Alvin E. Wang
- Hsin-Che Huang
- Charles D. Warren
- Qinghui Wang
- Isabelle H. Edmondson
- Andrew R. Griswold
- Sahana D. Rao
- Darren C. Johnson
- Daniel A. Bachovchin
04 Nov 2022
NO ACCESS

The oxidized form of thioredoxin-1 binds to and restrains NLRP1 inflammasome activation.

Abstract

The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to NLRP1. We found that oxidized TRX1 associates with the NACHT-LRR region of ...

OXPHOS promotes apoptotic resistance and cellular persistence in T_H17 cells in the periphery and tumor microenvironment

BY
- Hanna S. Hong
- Nneka E. Mbah
- Mengrou Shan
- Kristen Loesel
- Lin Lin
- Peter Sajjakulnukit
- Luis O. Correa
- Anthony Andren
- Jason Lin
- Atsushi Hayashi
- Brian Magnuson
- Judy Chen
- Zhaoheng Li
- Yuying Xie
- Li Zhang
- Daniel R. Goldstein
- Shannon A. Carty
- Yu Leo Lei
- Anthony W. Opipari
- Rafael J. Argüello
- Ilona Kryczek
- Nobuhiko Kamada
- Weiping Zou
- Luigi Franchi
- Costas A. Lyssiotis
18 Nov 2022
NO ACCESS

OXPHOS promotes apoptotic resistance and persistence in T_H17s by restricting mitophagy-mediated degradation of apoptotic regulators.

Abstract

T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune ...

Secondary infections rejuvenate the intestinal CD103⁺ tissue-resident memory T cell pool

BY
- Madlaina von Hoesslin
- Miriam Kuhlmann
- Gustavo Pereira de Almeida
- Kristiyan Kanev
- Christine Wurmser
- Ann-Katrin Gerullis
- Patrick Roelli
- Jacqueline Berner
- Dietmar Zehn
04 Nov 2022
NO ACCESS

Intestinal CD103⁺ T_rm lack secondary expansion potential and are replaced by de novo formed cells during reinfection.

Abstract

Resident T lymphocytes (T_RM) protect tissues during pathogen reexposure. Although T_RM phenotype and restricted migratory pattern are established, we have a limited understanding of their response kinetics, stability, and turnover during reinfections. Such ...

Local IL-23 is required for proliferation and retention of skin-resident memory T_H17 cells

BY
- Sarah K. Whitley
- Mushi Li
- Sakeen W. Kashem
- Toshiro Hirai
- Botond Z. Igyártó
- Kelley Knizner
- Jonhan Ho
- Laura K. Ferris
- Casey T. Weaver
- Daniel J. Cua
- Mandy J. McGeachy
- Daniel H. Kaplan
11 Nov 2022
NO ACCESS

IL-23 from CD301b⁺ myeloid cells sustains the skin T_H17 T_RM reservoir to promote antifungal immunity and psoriasis-like inflammation.

Abstract

The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear. In mice, we found that ...

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

BY
- Leslie Naesens
- Santoshi Muppala
- Dhiraj Acharya
- Josephine Nemegeer
- Delfien Bogaert
- Jung-Hyun Lee
- Katrien Staes
- Veronique Debacker
- Pieter De Bleser
- Marieke De Bruyne
- Elfride De Baere
- Michiel van Gent
- GuanQun Liu
- Bart N. Lambrecht
- Jens Staal
- Tessa Kerre
- Rudi Beyaert
- Jonathan Maelfait
- Simon J. Tavernier
- Michaela U. Gack
- Filomeen Haerynck
18 Nov 2022
Open Access

GTF3A mutations impair HSV-1 control by abrogating transcription of the endogenous RIG-I ligand RNA5SP141.

Abstract

Herpes simplex virus 1 (HSV-1) infects several billion people worldwide and can cause life-threatening herpes simplex encephalitis (HSE) in some patients. Monogenic defects in components of the type I interferon system have been identified in patients ...

Research Resource

Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus

BY
- Martijn Cordes
- Kirsten Canté-Barrett
- Erik B. van den Akker
- Federico A. Moretti
- Szymon M. Kiełbasa
- Sandra A. Vloemans
- Laura Garcia-Perez
- Cristina Teodosio
- Jacques J. M. van Dongen
- Karin Pike-Overzet
- Marcel J. T. Reinders
- Frank J. T. Staal
11 Nov 2022
NO ACCESS

Using immune profiling by single cell RNA-seq and spectral flow cytometry we show previously unrecognized insights into progenitor cells in the human thymus.

Abstract

T cell development in the mouse thymus has been studied extensively, but less is known regarding T cell development in the human thymus. We used a combination of single-cell techniques and functional assays to perform deep immune profiling of human T cell ...

Editors’ Choice

Taking the STING out

BY
- Young Kim
- Asha Pillai
04 Nov 2022
NO ACCESS

ABCC1 is an ATP-dependent cGAMP exporter responsible for negatively regulating STING signaling.

Abstract

ABCC1 is an ATP-dependent cGAMP exporter responsible for negatively regulating STING signaling.

Reports

CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques

BY
- Jinyan Liu
- Jingyou Yu
- Katherine McMahan
- Catherine Jacob-Dolan
- Xuan He
- Victoria Giffin
- Cindy Wu
- Michaela Sciacca
- Olivia Powers
- Felix Nampanya
- Jessica Miller
- Michelle Lifton
- David Hope
- Kevin Hall
- Nicole P. Hachmann
- Benjamin Chung
- Tochi Anioke
- Wenjun Li
- Jeanne Muench
- Adrienne Gamblin
- Mona Boursiquot
- Anthony Cook
- Mark G. Lewis
- Hanne Andersen
- Dan H. Barouch
11 Nov 2022
Open Access

In vivo CD8 T cell depletion in vaccinated macaques before SARS-CoV-2 challenge resulted in higher viral loads after challenge.

Abstract

Spike-specific neutralizing antibodies (NAbs) are generally considered key correlates of vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recently, robust vaccine prevention of severe disease with SARS-CoV-...

Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5

BY
- Alexander Muik
- Bonny Gaby Lui
- Maren Bacher
- Ann-Kathrin Wallisch
- Aras Toker
- Andrew Finlayson
- Kimberly Krüger
- Orkun Ozhelvaci
- Katharina Grikscheit
- Sebastian Hoehl
- Sandra Ciesek
- Özlem Türeci
- Ugur Sahin
18 Nov 2022
Open Access

BA.2 breakthrough infection leads to better BA.4/BA.5 nAbs.

Abstract

BNT162b2-vaccinated individuals after Omicron BA.1 breakthrough infection have strong serum-neutralizing activity against Omicron BA.1, BA.2, and previous SARS-CoV-2 variants of concern (VOCs) yet less against the highly contagious Omicron sublineages ...