COVER This image illustrates a transmembrane G protein–coupled receptor, GPR120, bound to an omega-3 fatty acid ligand, eicosapentaenoic acid, shown in bright orange. GPR120 recognizes unsaturated fatty acids, which contain cis double bonds, through a tight binding pocket within the membrane. Information about the identity of the ligand is propagated through the receptor to a G protein or to other signaling partners in the cell. See page eadd6220.
Illustration: C. Bickel/Science. Structural data: C. Mao et al, Science 380, eadd6220 (2023).