First Release

Selected Science Immunology papers are published online ahead of their issue date. Some editorial changes may occur between the First Release version and the final version.

14 Jun 2022

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

BY
- Paul Bastard
- Sara Vazquez
- Jamin Liu
- Matthew T. Laurie
- Chung Yu Wang
- Adrian Gervais
- Tom Le Voyer
- Lucy Bizien
- Colin Zamecnik
- Quentin Philippot
- Jérémie Rosain
- Emilie Catherinot
- Andrew Willmore
- Anthea M. Mitchell
- Rebecca Bair
- Pierre Garçon
- Heather Kenney
- Arnaud Fekkar
- Maria Salagianni
- Garyphallia Poulakou
- Eleni Siouti
- Sabina Sahanic
- Ivan Tancevski
- Günter Weiss
- Laurenz Nagl
- Jérémy Manry
- Sotirija Duvlis
- Daniel Arroyo-Sánchez
- Estela Paz Artal
- Luis Rubio
- Cristiano Perani
- Michela Bezzi
- Alessandra Sottini
- Virginia Quaresima
- Lucie Roussel
- Donald C. Vinh
- Luis Felipe Reyes
- Margaux Garzaro
- Nevin Hatipoglu
- David Boutboul
- Yacine Tandjaoui-Lambiotte
- Alessandro Borghesi
- Anna Aliberti
- Irene Cassaniti
- Fabienne Venet
- Guillaume Monneret
- Rabih Halwani
- Narjes Saheb Sharif-Askari
- Jeffrey Danielson
- Sonia Burrel
- Caroline Morbieu
- Yurii Stepanovskyy
- Anastasia Bondarenko
- Alla Volokha
- Oksana Boyarchuk
- Alenka Gagro
- Mathilde Neuville
- Bénédicte Neven
- Sevgi Keles
- Romain Hernu
- Antonin Bal
- Antonio Novelli
- Giuseppe Novelli
- Kahina Saker
- Oana Ailioaie
- Arnau Antolí
- Eric Jeziorski
- Gemma Rocamora-Blanch
- Carla Teixeira
- Clarisse Delaunay
- Marine Lhuillier
- Paul Le Turnier
- Yu Zhang
- Matthieu Mahevas
- Qiang Pan-Hammarström
- Hassan Abolhassani
- Thierry Bompoil
- Karim Dorgham
- COVID HGE consortium
- French COVID study group
- COMET consortium
- Guy Gorochov
- Cédric Laouenan
- Carlos Rodríguez-Gallego
- Lisa F. P. Ng
- Laurent Renia
- Aurora Pujol
- Alexandre Belot
- François Raffi
- Luis M. Allende
- Javier Martinez-Picado
- Tayfun Ozcelik
- Sevgi Keles
- Luisa Imberti
- Luigi D. Notarangelo
- Jesus Troya
- Xavier Solanich
- Shen-Ying Zhang
- Anne Puel
- Michael R Wilson
- Sophie Trouillet-Assant
- Laurent Abel
- Emmanuelle Jouanguy
- Chun Jimmie Ye
- Aurélie Cobat
- Leslie M. Thompson
- Evangelos Andreakos
- Qian Zhang
- Mark S. Anderson
- Jean-Laurent Casanova
- Joseph L. DeRisi
14 Jun 2022
Open Access

Type I IFN auto-Abs are found in 20% of hypoxemic, mRNA vaccinated COVID-19 patients despite SARS-CoV-2 neutralizing antibodies.

Abstract

Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% ...